Conference Proceedings
Genomics analyses of less common epithelial ovarian cancer subtypes.
Kylie L Gorringe, Matthew Wakefield, Sally M Hunter, Georgina L Ryland, Dane Cheasley, Michael S Anglesio, Michael Christie, Raghwa Sharma, Antill Yoland, Simone M Rowley, Jason Li, Blake Gilks, Prue E Allan, Andrew N Stephens, Sumi Ananda, Jan Pyman, Martin Koebel, Jessica McAlpine, Charlie Gourley, David G Huntsman Show all
CLINICAL CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2016
Abstract
Abstract While the genomics of high-grade serous carcinoma are well-studied in large international consortia, the less common subtypes have been neglected. We have sought to rectify this gap by analyzing international collections of low-grade serous and mucinous ovarian carcinomas and their putative benign and borderline precursors. Exome sequencing and copy number analysis of low-grade serous carcinomas (n=9) and serous borderline tumours (n=13) and targeted sequencing and copy number analysis in additional carcinomas (n=10) and borderline tumours (n=44) identified recurrent mutations in novel drivers such as EIF1AX and USP9X, as well as the known drivers KRAS,..
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